The Merlin team had a very successful plenary in Rotterdam on 10 and 11 May. Updates were presented on each WP. MSC production and preparation for the upcoming trial were naturally a key focus at this stage of the project. Publications and plans for future work were also discussed. Many thanks to EMC for hosting and to all the partners for their input into a very productive and enjoyable meeting!
A Merlin paper on the impact of long-term in vitro expansion on MSCs has been accepted for publication in Cytotherapy. The article is entitled “Aging of bone marrow and umbilical cord–derived mesenchymal stromal cells during expansion” (by Samantha de Witte (pictured above), Eleonora E. Lambert, Ana Merino, Tanja Strini, Hannie J.C.W. Douben, Lisa O’Flynn, Steve J. Elliman, Annelies J.E.M.M. de Klein, Philip N. Newsome, Carla C. Baan and Martin J. Hoogduijn). The corrected proof is now available on line: here. Congratulations to the authors!
The project team are pleased to issue the first Merlin Newsletter (for Autumn 2016). You can access the newsletter above. Contents in this edition include:
- MERLIN at a Glance – a reminder of the project’s key aims and objectives.
- Read All About it – details of some of our recent publications.
- At the Lectern – some key presentations delivered by the MERLIN team.
- Progress and Next Steps – where to find progress updates and a look at next steps.
- Meet the Team – the partners behind the project.
Merlin partner Orbsen hosted the latest Merlin plenary, held in Galway on 17 and 18 October. The meeting was very productive and included updates from all scientific work packages, aswell as reviews of IP, dissemination/exploitation and use of resources. Break-out sessions were also organised so that PIs and postdocs could collaborate in smaller groups. The team looks forward to delivering the work plan agreed for the weeks and months ahead.
An article published by Merlin researchers from UNIPD has recently been published in the “Leukemia” journal. The piece is entitled “Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1” (Author(s): Zanotti L, Angioni R, Calì B, Soldani C, Ploia C, Moalli F, Gargesha M, D’Amico G, Elliman S, Tedeschi G, Maffioli E, Negri A, Zacchigna S, Sarukhan A, Stein JV, Viola A) and appears in the May issue. The article deals with the impact of MSC on immunity and inflammation and identifies TIMP-1 as a novel biomarker for MSC-based therapy. You can access the article here.
In March 2015 we issued a report summarising the work undertaken during the first year of the project. Our second report, for year 2 of Merlin is now available. You can access the year 2 report below.
Dr. Madhu Gargesha of BioInVision presented a paper titled “MSC pre-treatments lead to better cell survival in mouse models of liver disease: A CryoViz Study” at the American Association of Immunologists (AAI) 2016 Conference in Seattle, Washington, USA, May 13-16 2016. The presentation was very well received and generated a lot of interest in the MERLIN project. You can find more details about the Conference here.
Researchers from Merlin project partner Erasmus MC recently made a number of presentations at the Dutch Transplantation Society Meeting held on 9 and 10 March 2016 in Groningen. These included a poster presentation about the Merlin project entitled “Optimizing the immunogenicity and immunomodulatory properties of MSC “, (S.F.H. de Witte et al). For more details see here.
MERLIN is developing stem cell-based therapies that specifically target the inflammatory components of liver disease. Our partners BioInVision have developed a cryo-imaging system for 3D, microscopic imaging – the CryoViz instrument. CryoViz enables you to do cellular and molecular imaging where you get colour anatomy and exactly-registered multi-spectral molecular fluorescence.
Check out our video, which shows 3D rendering from MSC Bio-distribution studies of a murine model using the CryoViz cryo-imaging system.
The group of Prof. Antonella Viola from University of Padua has recently published a review titled “Mesenchymal stem cells: myths and reality” in “Swiss Medical Weekly”, the official scientific publication of the Swiss Society of General Internal Medicine, the Swiss Society of Infectiology and the Swiss Society of Rheumatology. In this review, they identified what in their opinion remain the main open questions on MSC biology, attempting to distinguish the facts from the myths concerning endogenous and therapeutic MSC.
- RT @starstem2020: Gold #nanostars will act as a ‘contrast medium’ for Photo Acoustic Imaging or #PAI, greatly improving the image while hav… Time ago 10 Days via Twitter for iPhone
- The UK relative to other single payer-dominated healthcare markets for #RegenerativeMedicine therapies. Read: 70 ye… t.co/y6er646zVl Time ago 13 Days via Twitter Web Client
- Read @RegMedNet's complete cord blood research roundup t.co/WzgsxJgouD #cordblood t.co/hNY6eVSmoe Time ago 16 Days via Twitter Web Client
Follow @fp7merlin on twitter.
This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602363. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.