A new Merlin article on Optimisation of MSC has just been published in Stem Cell Research and Therapy. The piece is entitled “Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease” and was lead by Samantha de Witte from Erasmus MC in the Netherlands. The paper is open […]
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Entries by merlin_admin
The Merlin team had a very successful plenary in Rotterdam on 10 and 11 May. Updates were presented on each WP. MSC production and preparation for the upcoming trial were naturally a key focus at this stage of the project. Publications and plans for future work were also discussed. Many thanks to EMC for hosting […]
A Merlin paper on the impact of long-term in vitro expansion on MSCs has been accepted for publication in Cytotherapy. The article is entitled “Aging of bone marrow and umbilical cord–derived mesenchymal stromal cells during expansion” (by Samantha de Witte (pictured above), Eleonora E. Lambert, Ana Merino, Tanja Strini, Hannie J.C.W. Douben, Lisa O’Flynn, Steve […]
The project team are pleased to issue the first Merlin Newsletter (for Autumn 2016). You can access the newsletter above. Contents in this edition include: MERLIN at a Glance – a reminder of the project’s key aims and objectives. Read All About it – details of some of our recent publications. At the Lectern – […]
Merlin partner Orbsen hosted the latest Merlin plenary, held in Galway on 17 and 18 October. The meeting was very productive and included updates from all scientific work packages, aswell as reviews of IP, dissemination/exploitation and use of resources. Break-out sessions were also organised so that PIs and postdocs could collaborate in smaller groups. The […]
An article published by Merlin researchers from UNIPD has recently been published in the “Leukemia” journal. The piece is entitled “Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1” (Author(s): Zanotti L, Angioni R, Calì B, Soldani C, Ploia C, Moalli F, Gargesha M, D’Amico G, Elliman […]
In March 2015 we issued a report summarising the work undertaken during the first year of the project. Our second report, for year 2 of Merlin is now available. You can access the year 2 report below. MERLIN Report Year 2
Dr. Madhu Gargesha of BioInVision presented a paper titled “MSC pre-treatments lead to better cell survival in mouse models of liver disease: A CryoViz Study” at the American Association of Immunologists (AAI) 2016 Conference in Seattle, Washington, USA, May 13-16 2016. The presentation was very well received and generated a lot of interest in the […]
Researchers from Merlin project partner Erasmus MC recently made a number of presentations at the Dutch Transplantation Society Meeting held on 9 and 10 March 2016 in Groningen. These included a poster presentation about the Merlin project entitled “Optimizing the immunogenicity and immunomodulatory properties of MSC “, (S.F.H. de Witte et al). For more details […]
MERLIN is developing stem cell-based therapies that specifically target the inflammatory components of liver disease. Our partners BioInVision have developed a cryo-imaging system for 3D, microscopic imaging – the CryoViz instrument. CryoViz enables you to do cellular and molecular imaging where you get colour anatomy and exactly-registered multi-spectral molecular fluorescence. Check out our video, which shows […]
This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602363. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.