The Merlin partners met in Padua on 22 and 23 January for our most recent plenary. The team heard updates from workstreams across the project and discussed the reports to be submitted to the EU by the end of January. MSC manufacture and plans for the clinical trial were also a key focus. An exploitation […]
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S. de Witte of Erasmus University Medical Center in Rotterdam took to the road in 2017 to present MERLIN results at five conferences in Belgium, The Netherlands and Spain: · Erasmus MC, Science days of the Department of Internal Medicine, Antwerp Poster: IMPACT OF CULTURE EXPANSION AND INFLAMMATORY CYTOKINE CHALLENGE ON DNA METHYLATION PROFILES IN MSC […]
Hosted by Leiden University Medical Center, the EU MSC2 2017 meeting in Leiden, NL on September 12th and 13th will assemble twelve EU-funded, mesenchymal stromal cell-focussed consortia. Projects to be presented include: REDDSTAR, REACH, RETHRIM, Stellar, MERLIN, Nephstrom, SCIENCE, VISICORT and Adipoa-2, AUTOSTEM, BOOSTB4, SEPCELL, RESSTORE, and RESPINE. This two day, interactive meeting will be held at the Stadsgehoorzaal Leiden. Three overarching aspects of the EU-MSC2 meeting include: mechanisms of action and […]
MERLIN team at the Universitá degli Studi di Padova publish “Proteomic analysis of the secretome of human bone marrow-derived mesenchymal stem cells primed by pro-inflammatory cytokines” in the Journal of Proteomics, 21July 2017 Congratulations to all authors: Elisa Maffioli, Simona Nonnis, Roberta Angioni, Fabiana Santagata, Bianca Calí, Lucia Zanotti, Armando Negri, Antonella Viola, Gabriella Tedeschi. In […]
A new Merlin article on Optimisation of MSC has just been published in Stem Cell Research and Therapy. The piece is entitled “Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease” and was lead by Samantha de Witte from Erasmus MC in the Netherlands. The paper is open […]
The Merlin team had a very successful plenary in Rotterdam on 10 and 11 May. Updates were presented on each WP. MSC production and preparation for the upcoming trial were naturally a key focus at this stage of the project. Publications and plans for future work were also discussed. Many thanks to EMC for hosting […]
A Merlin paper on the impact of long-term in vitro expansion on MSCs has been accepted for publication in Cytotherapy. The article is entitled “Aging of bone marrow and umbilical cord–derived mesenchymal stromal cells during expansion” (by Samantha de Witte (pictured above), Eleonora E. Lambert, Ana Merino, Tanja Strini, Hannie J.C.W. Douben, Lisa O’Flynn, Steve […]
The project team are pleased to issue the first Merlin Newsletter (for Autumn 2016). You can access the newsletter above. Contents in this edition include: MERLIN at a Glance – a reminder of the project’s key aims and objectives. Read All About it – details of some of our recent publications. At the Lectern – […]
Merlin partner Orbsen hosted the latest Merlin plenary, held in Galway on 17 and 18 October. The meeting was very productive and included updates from all scientific work packages, aswell as reviews of IP, dissemination/exploitation and use of resources. Break-out sessions were also organised so that PIs and postdocs could collaborate in smaller groups. The […]
An article published by Merlin researchers from UNIPD has recently been published in the “Leukemia” journal. The piece is entitled “Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1” (Author(s): Zanotti L, Angioni R, Calì B, Soldani C, Ploia C, Moalli F, Gargesha M, D’Amico G, Elliman […]
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This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602363. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.