The MERLIN study “Epigenetic changes in umbilical cord mesenchymal stromal cells upon stimulation and culture expansion” has been recently published in Cytotherapy The Journal of Cell Therapy. The body of research by Samantha F.H. de Witte1, Fleur S. Peters1, Ana Merino1, Sander S. Korevaar1, Joyce B.J. van Meurs2, Lisa O’Flynn3, Steve J. Elliman3, Philip N. Newsome4–6, […]
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Head of Process Development at Orbsen Therapeutics, Limited, Dr Lisa O’ Flynn attended the 3rd Annual Bioprocessing and Advanced Cellular Therapies Congress in Frankfurt, Germany. The meeting was held on the 29th-30th of May 2018. Lisa gave an oral presentation entitled ” CD362 to ORBCEL: the rapid development of a novel stromal cell therapy ” wherein […]
Roberta Angioni of the Department of Biomedical Science at the University of Padua presented MERLIN’s objectives and results during an invited talk entitled “Mesenchymal stem cells and their extracellular vesicles in the control of pathological angiogenesis” at the Pediatric Research Institute (IRP) meeting held April 7, 2018, at the Villa Pace Park Hotel, Preganziol in Treviso, Italy. Roberta […]
A new MERLIN publication led by our team at Erasmus MC in Rotterdam, NL appeared in the journal Stem Cells on 17 January 2018. Authors of this paper are: Samantha F H de Witte , Franka Luk, Jesus M Sierra Parraga, Madhu Gargesha, Ana Merino, Sander S Korevaar, Anusha S Shankar, Lisa O’Flynn, Steve J Elliman, […]
The Merlin Newsletter for Winter 2017 – 2018 has just been issued! This is the second edition of our newsletter and includes the following sections: Refresher Course – a reminder of the project’s key aims and objectives Forging Ahead – a brief update on recent progress Read All About it – details of some of […]
The Merlin partners met in Padua on 22 and 23 January for our most recent plenary. The team heard updates from workstreams across the project and discussed the reports to be submitted to the EU by the end of January. MSC manufacture and plans for the clinical trial were also a key focus. An exploitation […]
S. de Witte of Erasmus University Medical Center in Rotterdam took to the road in 2017 to present MERLIN results at five conferences in Belgium, The Netherlands and Spain: · Erasmus MC, Science days of the Department of Internal Medicine, Antwerp Poster: IMPACT OF CULTURE EXPANSION AND INFLAMMATORY CYTOKINE CHALLENGE ON DNA METHYLATION PROFILES IN MSC […]
Hosted by Leiden University Medical Center, the EU MSC2 2017 meeting in Leiden, NL on September 12th and 13th will assemble twelve EU-funded, mesenchymal stromal cell-focussed consortia. Projects to be presented include: REDDSTAR, REACH, RETHRIM, Stellar, MERLIN, Nephstrom, SCIENCE, VISICORT and Adipoa-2, AUTOSTEM, BOOSTB4, SEPCELL, RESSTORE, and RESPINE. This two day, interactive meeting will be held at the Stadsgehoorzaal Leiden. Three overarching aspects of the EU-MSC2 meeting include: mechanisms of action and […]
MERLIN team at the Universitá degli Studi di Padova publish “Proteomic analysis of the secretome of human bone marrow-derived mesenchymal stem cells primed by pro-inflammatory cytokines” in the Journal of Proteomics, 21July 2017 Congratulations to all authors: Elisa Maffioli, Simona Nonnis, Roberta Angioni, Fabiana Santagata, Bianca Calí, Lucia Zanotti, Armando Negri, Antonella Viola, Gabriella Tedeschi. In […]
A new Merlin article on Optimisation of MSC has just been published in Stem Cell Research and Therapy. The piece is entitled “Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease” and was lead by Samantha de Witte from Erasmus MC in the Netherlands. The paper is open […]
- The MERLIN study “Epigenetic changes in umbilical cord mesenchymal stromal cells upon stimulation and culture expan… t.co/apCTuxvBqG Time ago 9 Hours via Twitter Web Client
- Looking for vacancies in the #stemcell arena? Have you visited t.co/5snVj6rUPV or t.co/XYqojq2jsf? Best of luck! Time ago 3 Days via Twitter Web Client
- An excellent video (Thanks @LiverTrust) overviewing #PSC including the currently-available treatments: immunosuppre… t.co/kaLFLe6fWB Time ago 6 Days via Twitter Web Client
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This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602363. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.